Sandeep Upadhyay • Published Articles (25)

Articles, Essays & Publications

Comprehensive archive of published articles, systems thinking frameworks, life sciences analytics strategy, and AI architectural deep-dives from 2014 to present.

All Articles (25)

2014 – 2026 Archive
article7 min read

How Smart Design Converts Local Edge LLMs into Gamechangers

I built Aperio Health (formerly Medical 360) as a passion project. The intent was simple, have a system that provides clinical grade information on any drug, disease state, pathogens etc. as an alternative to google search.

#Local LLMs & GenAI#Healthcare & Life Sciences
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article3 min read

When a 2017 “What‑If” Finally Got Its Moment in the Age of GenAI

In 2017, a chance meeting with a marketeer drew me to an interesting problem.

#Local LLMs & GenAI#Healthcare & Life Sciences
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article5 min read

Dr. ChatGPT will see you now...

It all began on **Friday, June 6th**, with what felt like simple fatigue. Suddenly my eyes were heavy and tired, and I chalked it up to a long work week, or maybe some screen overuse, or recovering from the viral throat infection a week prior.

#Local LLMs & GenAI#Healthcare & Life Sciences
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article4 min read

The Human Factor: Why Big Tech Ideas Need Smart Pacing – Lessons from Microsoft

At its heart, every business venture, every new product, every bold strategy is a gamble—a gamble on how people will react. Companies pour fortunes into these bets, hoping we'll eagerly adopt their latest creations or change our comfortable routines. But here’s a truth that often gets sidelined in t...

#Business Intelligence & Analytics
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article6 min read

Transforming Pharma Analytics with Systems Thinking/ Modeling and Agentic AI

In the rapidly evolving world of data and analytics, technological advancements have predominantly focused on two areas: descriptive analytics (understanding what happened, and when) and predictive analytics (for forecasting what will happen).

#Local LLMs & GenAI#Healthcare & Life Sciences
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article3 min read

The Smartphone Epidemic: A Global Addiction Crisis

In our hyper-connected world, smartphones have become an indispensable part of our lives. However, this convenience comes with a dark side: a growing epidemic of smartphone addiction. The constant need for dopamine hits from notifications, social media, and apps has severe consequences on our brains...

#Business Intelligence & Analytics
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article3 min read

Can it (genAI) solve wordle?

For a very long time, the running theme for high end consumer pc's and cutting edge graphics cards was "Can it play Crysis?". Crysis as a game had garnered a reputation to melt the most cutting edge PC's and bring them down on their knees.

#Local LLMs & GenAI#Business Intelligence & Analytics
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article3 min read

Decoding the World : How Data Uncovers the Hidden Rules

In the competitive world of business, navigating the ever-changing landscape can feel like deciphering an ancient language.

#Business Intelligence & Analytics
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article3 min read

The Socio-Economic Potential of AI

For a long time, English has been the dominant language of business in the global market.

#Local LLMs & GenAI#Business Intelligence & Analytics
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article3 min read

Auto Insurance & Conway's Law

Earlier in July, I had the misfortune of having my car dinged badly at a grocery store parking lot. It seemed like the driver in the adjacent lane had miscalculated the angle of reverse and side-swiped the back. She was honest enough to leave her phone number on the windshield of my car, asking me t...

#Local LLMs & GenAI#Business Intelligence & Analytics
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article5 min read

digital (deflection) is killing consumer (support) experience

Recently I purchased a product on Amazon. Unfortunately, it came damaged, and I had to return it. Amazon’s returns process is a breeze. With a few clicks, I selected the nearest UPS store as a drop point and returned it there.

#Business Intelligence & Analytics
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article6 min read

MedTech Firms - "Houston - We have a problem!"​

It’s the year 1999. I am sitting alongside 378 other batchmates intently listening to the professor teaching us about factor of safety in an engineering design class.

#Local LLMs & GenAI#Healthcare & Life Sciences
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article3 min read

Who am I on LinkedIn?

I woke up today morning to an interesting piece of news from Endpoints Pharma watchdog calls out AstraZeneca, GlaxoSmithKline for breaches on online conduct – Endpoints News (endpts.com)

#Healthcare & Life Sciences#Business Intelligence & Analytics
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article3 min read

Contextual Intelligence - Enabling Organizations to shift from "Data Driven Businesses"​ to "Insights Driven Businesses"​

Business intelligence, analytics & reporting as a capability across most organizations is fractured.

#Business Intelligence & Analytics#Data Strategy
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article4 min read

The Personalized Marketing Arms Race

A while back, I was in the market for a smartwatch. Like any consumer I researched a few smartwatch options like Misfit, Fossil, Samsung, Garmin etc. and finally chose a watch that I liked. I researched online but chose to pickup from store.

#Local LLMs & GenAI#Business Intelligence & Analytics
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article6 min read

MedTech Firms Cannot Compete With Consumer Grade Devices

***Disclaimer: ****The post is equal parts frustration and reflection on my experience with Dexcom G6. While this is specific to a one device, the frustrations are applicable to other CGM alternatives in the market as well*

#Healthcare & Life Sciences#Business Intelligence & Analytics
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article4 min read

What They Don't Teach You Anywhere - Excel

bEver so often I come across documents created by my team that make me cringe within. And it wasn't long ago when I had started my career in 2003 (ok it was long ago) that the documents I would create would make my team leaders cringe as well.

#Local LLMs & GenAI#Business Intelligence & Analytics
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article3 min read

Business Intelligence - The Path Ahead

In my previous post, "Business Intelligence is Dead. Long Live Business Intelligence", I had shared my perspectives about the inherent challenges that lead to poor adoption of Business Intelligence applications.

#Business Intelligence & Analytics
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article4 min read

Business Intelligence is Dead. Long Live Business Intelligence!!

A few weeks ago, I was conversing with the VP of Commercial IT at a large medical device firm on his priorities and the future of his organization. He looked at me and said "Currently everything that we do as a team is create ETL or create Reports & Dashboards. I call it DnD - Dungeons & Dragons. Th...

#Local LLMs & GenAI#Healthcare & Life Sciences
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article3 min read

who's data strategy is it anyways?

In a recent conversation, the head of data strategy & analytics at a large biopharmaceutical company shared his thoughts around data strategy.

#Healthcare & Life Sciences#Business Intelligence & Analytics
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article4 min read

Wait...I have CLL! Whaaaaaaaaaat!

A health scare earlier in the year made me reflect upon the inadequacy of medical literacy in today’s world and form perspectives on the journey patients take to understand more on their (current or potential) disease state.

#Healthcare & Life Sciences#Business Intelligence & Analytics
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article3 min read

Lessons from a Sushi Master

We tend draw inspirations from the unlikeliest of places.

#Business Intelligence & Analytics
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article3 min read

What's Your Signature?

Do you love your signature? I sure do love mine.

#Local LLMs & GenAI#Business Intelligence & Analytics
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article3 min read

Technology - The Greatest Equalizer

My first biggest lesson from my first job. **"Technology is the greatest equalizer"**. It doesn't take long for an expert to become a novice and a novice to become an expert. We need to stay busy, stay hungry, keep on learning new things and constantly upgrading ourselves.

#Business Intelligence & Analytics
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article3 min read

The "New" Boy Phenomenon

Sharing a personal experience that happened when I was 11 years old and has stuck with me since then.

#Business Intelligence & Analytics
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